Abstract. The objective of this letter is to provide a perspective on the impact of multiple sclerosis (MS) on postural control and gait and suggestions for future studies. Although studies on MS with postural control and gait have been carried out for some time, in Brazil and in the World, there is still insufficient information on MS and impairments in postural control and gait.Postural control and gait impairments are recognized to cause several problems for people with MS, these being two of the symptoms that most affect quality of life.Here, we present studies that have investigated impairments in postural control and gait using different experimental designs and discuss the adaptations of the central nervous system (CNS) due to the damage caused by MS.We recommend future studies focus on how the CNS is organized towards postural control and gait, with a better ecological approach, which could assist the development of rehabilitation programs.